Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disorder. It is caused by prions, which are abnormally folded proteins that induce normal proteins in the brain to misfold. CJD primarily affects older adults (sporadic form) worldwide, leading to rapid mental and physical deterioration.
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Creutzfeldt-Jakob disease was first described in the early 1920s by German neurologists Hans Gerhard Creutzfeldt and Alfons Maria Jakob. Its significance grew with the understanding of transmissible spongiform encephalopathies (TSEs), particularly the link between **variant CJD** and bovine spongiform encephalopathy (BSE) in the 1990s, highlighting the unique nature of prion diseases.
CJD is not contagious through casual contact. Most cases are **sporadic**, meaning they occur spontaneously without a clear cause. Transmission can also occur through medical procedures (**iatrogenic CJD**) involving contaminated brain tissue or instruments, or through inheritance (**familial CJD**); **variant CJD (vCJD)** is acquired by consuming contaminated beef products.
Période de Contagiosité : Varies by disease
1 country with reported activity. Updated from real-time surveillance data.
Renseignements en temps réel issus de la surveillance sanitaire mondiale et de la surveillance par IA
Sources de données : BEACON, ProMED, OMS, CDC et plus de 50 agences nationales de santé
✓ Données en direct mises à jour en temps réel depuis les sources de santé mondiales
Variant Creutzfeldt-Jakob disease (vCJD) is a fatal prion disorder linked to dietary exposure to bovine spongiform encephalopathy (BSE). The epidemic peaked in the early 2000s, and no new cases have been reported in the UK since 2016. However, uncertainties remain regarding potential future cases, particularly in individuals with non-MM prion protein gene codon 129 genotypes, and possible secondary transmission via blood transfusion. We aimed to update risk estimates with recent data, informed by a probabilistic modelling approach. We developed a cohort-based probabilistic model for variant CJD incidence incorporating genotype-specific attack rates and incubation periods, accounting for competing mortality risks. Model parameters were calibrated using historical case data and life-table an...
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Informations fiables provenant des principales organisations de santé
Directives officielles des Centers for Disease Control and Prevention des États-Unis
Voir les Ressources du CDC →Surveillance mondiale des maladies et directives de l'Organisation Mondiale de la Santé
Voir les Ressources de l'OMS →Les informations sur les maladies sur Virus Watcher sont révisées par notre Épidémiologiste en Chef, ancien analyste principal du CDC pour les prévisions FluSight. Les données épidémiques sont agrégées à partir de sources vérifiées notamment BEACON, ProMED, OMS, CDC et plus de 50 agences nationales de santé. Ces informations sont à des fins éducatives et ne doivent pas remplacer les conseils médicaux professionnels.
Dernière révision : 2026-08-13
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