Hemorrhagic fever with renal syndrome (HFRS) is a severe viral illness caused by *hantaviruses*. It primarily affects humans, especially in rural areas of Asia and Europe, leading to fever, bleeding disorders, and acute kidney damage. The disease's severity varies depending on the specific hantavirus type.
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HFRS has been recognized for centuries in East Asia but gained significant attention during the Korean War (1950s) due due to severe outbreaks among soldiers. The causative agent, *Hantaan virus*, was isolated in 1978 by Dr. Ho-Wang Lee, marking a major breakthrough in understanding and combating the disease.
HFRS is transmitted to humans primarily through the inhalation of aerosolized particles contaminated with the urine, feces, or saliva of infected rodents. Direct contact with infected rodents or their droppings, or consuming contaminated food or water, can also lead to infection. The disease is *not* transmitted from person to person.
Contagious Period: Varies by disease
Local health department information and state-specific prevention guidance
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Whether you live in Montana or are traveling there, knowing the symptoms, timeline, and when to seek care helps you act quickly if exposure occurs.
Seek care if you experience severe dehydration, bloody stools, high fever, or symptoms lasting more than 3 days. Children under 5, adults over 65, and immunocompromised individuals should seek care earlier.
Emergency symptoms: Severe dehydration, inability to keep fluids down for 12 or more hours, or neurological symptoms require emergency care.
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Trusted information from leading health organizations
Official guidance from the U.S. Centers for Disease Control and Prevention
View CDC Resources βGlobal disease surveillance and guidelines from the World Health Organization
View WHO Resources βDisease information on Virus Watcher is reviewed by our Chief Epidemiologist, a former CDC lead analyst for FluSight forecasting. Outbreak data is aggregated from verified sources including BEACON, ProMED, WHO, CDC, and 50+ national health agencies. This information is for educational purposes and should not replace professional medical advice.
Last reviewed: 2026-07-18
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